Immuno-therapeutic approaches

Our aims are the formulation of innovative vaccines (against infectious and not-infectious diseases) and the design of strategies for targeting specific cell subsets using antigen nanocarriers. We design vaccine with free and/or NP bound recombinant allergens to modulate allergen specific immune response, and propose Fcγ-chimeric receptor engineered T and NK cell for the treatment of hematologic and solid tumors. Moreover we study the effects of compounds and natural substances on cell mediated immunity, the role of HLA-DR in immune escape and metastatic progression and we propose gene correction and gene editing of primary immunodeficiencies (RAG defects)..