Giovanna Del Pozzo

+0816132309-335233857 | giovanna.delpozzo@cnr.it

Institute
Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”
Via Pietro Castellino 111 , 80131 Napoli
http://www.igb.cnr.it/index.php/giovanna-del-pozzo/

Federica Spetrini (student)
Marcella D’Ambrosio (Fellow)

Patent of a new assay for celiac disease diagnosis: G.A.T. CD4, gliadin activated CD4+ T cells (Rif. CNR 11009 – ID n .2426; EP4600651).
Analysis of the immune response of gliadin-specific CD4+ T lymphocytes in adult and pediatric patients with active celiac disease and patients in remission after gluten-free diet.

Study of HLA class II genes expression in antigen presenting cells from patients affected by autoimmunity.
Analysis of immunomodulatory role of exosomes

• 1. Pisapia L, D’Ambrosio M, Mottola I, Picascia S, De Girolamo D, Castiglione F, Tinto N, Rispo A, Gianfrani C, Del Pozzo G. Detection of Gliadin-Activated CD4+ T Cells Is a New Assay to Reveal Pathogenic Lymphocytes in Celiac Disease. J Cell Mol Med. 2025 Oct;29(20):e70898. doi: 10.1111/jcmm.70898.S
• 2. S Sartoris, G Del Pozzo. Exploring the HLA complex in autoimmunity: From the risk haplotypes to the modulation of expression. Clinical Immunology Aug.2024. 265, 110266
• 3. M Laezza, L Pisapia, B Toro, V Mercadante, A Rispo, C Gianfrani, G. Del Pozzo. Changes upon the gluten-free diet of HLA-DQ2 and TRAFD1 gene expression in peripheral blood of celiac disease patients. Journal of Translational Autoimmunity. Jun 2024. 8, 100240

 Primary Cell and immortalized cell lines culture, gene expression (ddPCR,qPCR), flow cytometry, mouse and microscopy facilities.