Maria Pia Fuggetta

39-06-49934610 – 4259
mariapia.fuggetta@ift.cnr.it

Institute
Institute of Translational Pharmacology – Rome
Via Fosso del Cavaliere 100 – 00133 Roma
Tel. +39 06 45488486
http://www.ift.cnr.it

• Prof. Enzo Bonmassar,
  Senior Research Associate

• Prof. Giampiero Ravagnan
  Senior Research Associate

• Effects of drugs and natural substances on Cell Mediated Immunity: CTL/NK cytotoxicity
• Drug-induced Neoantigens on tumour cells (Xenogenization,DIX) Antigen specific recognition by CTL
• Control of inflammation by natural substances : in vitro models of inflammation and Inflammation in obesity (model of obesity in vitro)
• Immunologyc effects of Resveratrol/Polydatin (Spinoff) • Effects of new inhibitors of the “Inflammasome-Caspase-1
• Effects of new inhibitors of the “Inflammasome-Caspase-1 Complex” new molecules which, by inhibiting Interleukin -1β, can control autoimmune and inflammatory disorders (collaboration with ICB/CNR Sassari )

• In vitro tumor growth(apoptosis telomerase activity)
• In vitro cellular immunology
• NK and CTL cytotoxic activity (Test 51Cr release- or colorimetric)
• In vitro model of cell/cell interaction (cellular cross talk)
• Immune Cell separation
• ELISPOT
• Cytokines production (TEST ELISA)
• Western blot

Academic SPINOFF www.glures.it

PATENTS:

2 international patents: (PCT / IB01 / 00983) and (PCT / IB2001 / 00981) concerning the extraction methods and the antitumor and immunomodulatory effects of Resveratrol and its glucoside derivative POLYDATIN . The patents were the basis of the academic SPINOFF, participated CNR, represented by GLURES srl company. The patent (PCT / IB01 / 00983) has been licensed for use and has resulted in the marketing of Polydatin-based products: a “supplement for special medical purposes” containing 100% Polydatin and a dermocosmetic product.
Clinical studies are in progress