Organic Synthesis and Bioactive Molecules (Syn@BioMol)
Group Leader : Pietro Spanu
The Institute of Biomolecular Chemistry
Contact
Pietro Spanu
+39 079 2841221 | +39 0792841222
p.spanu@icb.cnr.it
Institute
The Institute of Biomolecular Chemistry S.S. Sassari
Traversa La Crucca, 1, 07100 San Giovanni SS
Tel. +39 0792841203
http://www.icb.cnr.it/
Lab Members
- Dr Pietro Spanu (I ric) p.spanu@icb.cnr.it
- Dr. Fausta Ulgheri (ric) f.ulgheri@icb.cnr.it
- Dr. Francesco Deligia francesco.deligia@ss.icb.cnr.it
- Dr. Maria Cristina Porcu (tecnico) cristina.porcu@ss.icb.cnr.it
Activities
We are interested in the role of innate immune activation and inflammation in the pathogenesis of major neurodegenerative diseases. Our targets are new small molecules able to modulate inflammatory processes useful in the therapy of neurological disorders, and we are working on design, synthesis and characterization of new caspase-1 inhibitors as lead compounds for neurodegenerative diseases. We discovered a new class of selective, non-covalent, non-peptidic caspase-1 inhibitors that mediate neuroprotection against glutamate toxicity and are able to cross the blood-brain-barrier.
Istrument & technologies
NMR, HPLC,MCR and asymmetric synthesis
Other relevant information
NMR, HPLC,MCR and asymmetric synthesis