Group Leader :
Veronica De Rosa

+39-3472738870 | veronica.derosa@cnr.it  

Institute
Institute of Endotypes in Oncology, Metabolism and Immunology
18° Building, 4th floor
Via Sergio Pansini 5, 80131 NA
http://www.su.ieos.cnr.it/

Antonietta Liotti | antonietta.liotti@unina.it
Valeria Mazzone | valeria.mazzone@cnr.it
Annamaria Szabò | annamaria.szabo16@gmail.com
Maedeh Dehbozorgi | m.dehbozorgi@studenti.unina.it

The research focuses on characterizing the molecular mechanisms (epigenetic and transcriptional) that control the development, differentiation, and function of regulatory and effector T cells, both under physiological conditions and in diseases characterized by altered tolerance (immunodeficiency, cancer and autoimmunity) or by inflammation and senescence (obesity, T2D, aging).

• Fusco C, Di Rella F, Liotti A, Colamatteo A, Ferrara AL, Gigantino V, Collina F, Esposito E, Donzelli I, Porcellini A, Feola A, Micillo T, Perna F, Garziano F, Maniscalco GT, Varricchi G, Mottola M, Zuccarelli B, De Simone B, di Bonito M, Matarese G, Accurso A, Pontillo M, Russo D, Insabato L, Spaziano A, Cantone I, Pezone A, De Rosa V. CD4+FOXP3Exon2+ regulatory T cell frequency predicts breast cancer prognosis and survival. Science Advances. 2025 Jan 17;11(3):eadr7934. doi: 10.1126/sciadv.adr7934. Epub 2025 Jan 15. PMID: 39813341
• Xiaofei Li, Alessandra Colamatteo, Lydia Kalafati, Tetsuhiro Kajikawa, Hui Wang, Jong-Hyung Lim, Khalil Bdeir, Kyoung-Jin Chung, Xiang Yu, Clorinda Fusco, Antonio Porcellini, Salvatore De Simone, Giuseppe Matarese, Triantafyllos Chavakis, De Rosa V*, George Hajishengallis* (2020). The DEL-1/Œ≤3 integrin axis promotes regulatory T cell responses during inflammation resolution. THE JOURNAL OF CLINICAL INVESTIGATION, vol. 130, p. 6261-6277, ISSN: 1558-8238, doi: 10.1172/JCI137530. *co-last author
• Colamatteo A, Maggioli E, Azevedo Loiola R, Hamid Sheikh M, Cal√¨ G, Bruzzese D, Maniscalco GT, Centonze D, Buttari F, Lanzillo R, Perna F, Zuccarelli B, Mottola M, Cassano S, Galgani M, Solito E, De Rosa V. Reduced Annexin A1 Expression Associates with Disease Severity and Inflammation in Multiple Sclerosis Patients. J Immunol. 2019 Oct 1;203(7):1753-1765. doi: 10.4049/jimmunol.1801683. Epub 2019 Aug 28. PMID: 31462505
• De Rosa V, Galgani M, Porcellini A, Colamatteo A, Santopaolo M, Zuchegna C, Romano A, De Simone S, Procaccini C, La Rocca C, Carrieri PB, Maniscalco GT, Salvetti M, Buscarinu MC, Franzese A, Mozzillo E, La Cava A, Matarese G. Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants. Nature Immunology. 2015 Nov;16(11):1174-84. doi: 10.1038/ni.3269. Epub 2015 Sep 28. PMID: 26414764
• Carbone F*, De Rosa V*, Carrieri PB, Montella S, Bruzzese D, Porcellini A, Procaccini C, La Cava A, Matarese G. Regulatory T cell proliferative potential is impaired in human autoimmune disease. Nature Medicine. 2014 Jan;20(1):69-74. doi: 10.1038/nm.3411. Epub 2013 Dec 8. Nature Medicine. 2014 Feb;20(2):220. PMID: 24317118. *co first author

ELISA microplate reader, Ella Automated Immunoassay System, electroporator, MACSQuant flow cytometer (Miltenyi), gentleMACS™ dissociator (Miltenyi), spectral flow cytometer SONY ID7000, High-Content Analysis Operetta system, RT-PCR and Real-time PCR instruments, chemiDoc imaging system (Bio-Rad), microscopes, benchtop centrifuges and small centrifuges.