Claudio Procaccini 

+39-0817464580 |claudio.procaccini@cnr.it
Fortunata Carbone (III livello)

+39-0817464580 |fortunate.carbone@cnr.it
 Claudia La Rocca (III livello)

+39-0817464580 |claudia.larocca@cnr.it

Institute 
Institute of Endotypes in Oncology, Metabolism and Immunology “Gaetano Salvatore” 
Via S. Pansini 5, 80131 Naples
https://www.su.ieos.cnr.it/

Giusy De Rosa (Post-doc)
Teresa Micillo (Post-doc)
Clorinda Fusco (Post-doc)
Gianmarco Esposito (fellow)
Vincenzo Di Marino (PhD student)
Kristyna Ruggiero (PhD student

• Investigation of the cellular and molecular mechanisms regulating immunological self-tolerance and regulatory T (Treg) cell homeostasis.

• Characterization of the metabolic pathways and molecular programs governing Treg cell differentiation, stability, and function in physiological and pathological conditions.

• Study of the interplay between immune responses and cellular metabolism in health and disease, with a particular focus on autoimmune disorders, including Multiple Sclerosis (MS) and Type 1 Diabetes (T1D), as well as infectious diseases.

• Study of the immunological mechanisms underlying the pathogenesis of obesity.

• Effects of diet-based therapeutic strategies in the modulation of immune tolerance

• Identification and validation of novel biomarkers for disease prognosis, progression, and therapeutic response in autoimmune diseases, particularly MS

1.De Rosa G, Russo C, Garavelli S, Di Silvestre D, Spatocco I, Mele G, La Rocca C, Colamatteo A, Carbone F, Fusco C, Passaro F, Carpi D, Tagliabue E, Prattichizzo F, Brambilla F, Mauri P, Hoxha M, Bollati V, Giusti I, Dolo V, D’Antona P, Campomenosi P, Mangolini V, Radeghieri A, Bergese P, Morabito I, Mandelli A, Finardi A, Beretta F, Schilke ED, Cavaletti G, Dolcetti E, Buttari F, Abbadessa G, Bonavita S, Lus G, Signoriello E, Lanzillo R, Morra VB, Mottola M, Zuccarelli B, Uccelli A, Salvetti M, Centonze D, Furlan R, Matarese G, Procaccini C*, de Candia P*.(*co-last and co-corresponding authors). MicroRNA-142-3p shuttling in extracellular vesicles marks regulatory T cell dysfunction in multiple sclerosis. Sci Transl Med. 2025 May 28;17(800):eadl1698. doi: 10.1126/scitranslmed.adl1698. Epub 2025 May 28. PMID: 40435218.

2. Procaccini C, Garavelli S, Carbone F, Di Silvestre D, La Rocca C, Greco D, Colamatteo A, Lepore MT, Russo C, De Rosa G, Faicchia D, Prattichizzo F, Grossi S, Campomenosi P, Buttari F, Mauri P, Uccelli A, Salvetti M, Brescia Morra V, Vella D, Galgani M, Mottola M, Zuccarelli B, Lanzillo R, Maniscalco GT, Centonze D, de Candia P, Matarese G. Signals of pseudo-starvation unveil the amino acid transporter SLC7A11 as key determinant in the control of Treg cell proliferative potential. Immunity. 2021 Jul 13;54(7):1543-1560.e6. doi: 10.1016/j.immuni.2021.04.014. Epub 2021 May 17. PMID: 34004141.

3. Procaccini C, Carbone F, Di Silvestre D, Brambilla F, De Rosa V, Galgani M, Faicchia D, Marone G, Tramontano D, Corona M, Alviggi C, Porcellini A, La Cava A, Mauri P, Matarese G. The Proteomic Landscape of Human Ex Vivo Regulatory and Conventional T Cells Reveals Specific Metabolic Requirements. Immunity. 2016 Feb 16;44(2):406-21. doi: 10.1016/j.immuni.2016.01.028. PMID: 26885861; PMCID: PMC4760097.

4. Palma C, La Rocca C, Gigantino V, Aquino G, Piccaro G, Di Silvestre D, Brambilla F, Rossi R, Bonacina F, Lepore MT, Audano M, Mitro N, Botti G, Bruzzaniti S, Fusco C, Procaccini C, De Rosa V, Galgani M, Alviggi C, Puca A, Grassi F, Rezzonico-Jost T, Norata GD, Mauri P, Netea MG, de Candia P, Matarese G. Caloric Restriction Promotes Immunometabolic Reprogramming Leading to Protection from Tuberculosis. Cell Metab. 2021 Feb 2;33(2):300-318.e12. doi: 10.1016/j.cmet.2020.12.016. Epub 2021 Jan 8. PMID: 3342138.

5.Carbone F, De Rosa V, Carrieri PB, Montella S, Bruzzese D, Porcellini A, Procaccini C, La Cava A, Matarese G. Regulatory T cell proliferative potential is impaired in human autoimmune disease. Nat Med. 2014 Jan;20(1):69-74. doi: 10.1038/nm.3411. Epub 2013 Dec 8. PMID: 24317118

Multiparametric/spectral Flow Cytometry (SONY ID7000), cell sorting (SONY MA900), in vivo murine models of obesity and autoimmunity, Seahorse technology (Agilent), Luminex technology, western blotting, Real Time PCR machine, AutoMacs Separator