Angelo Fontana 
+39 081 8675018 

fontana@cnr.it

Institute
Institute of Biomolecular Chemistry
Via Campi Flegrei, 34 80078 Pozzuoli (NA)
https://www.icb.cnr.it/

• Carmela Gallo
• Emiliano Manzo
• Genoveffa Nuzzo
• Giuliana d’Ippolito
• Daniela Castiglia
  

The group activity focuses on small, naturally derived molecules with pharmaceutical relevance, particularly in the areas of immunology and oncology, and on their application as tools to explore and modulate complex biological systems. Research activities include the discovery and characterization of bioactive compounds from marine organisms, investigation of their biosynthetic pathways and regulatory mechanisms, and the design of molecules that interact with cellular targets to influence key biological processes. A translational research approach is adopted, bridging basic science with medical and biotechnological applications, through the integration of organic chemistry, chemical biology, and advanced analytical technologies.

• Fioretto, L. et al. BODIPY-Based Analogue of the TREM2-Binding Molecular Adjuvant Sulfavant A, a Chemical Tool for Imaging and Tracking Biological Systems, ACS 96, 8 (2024)
• Carbone, D. et al. Marine natural product lepadin A as a novel inducer of immunogenic cell death via CD91-dependent pathway, Natural Products and Bioprospecting 13 (1), 34 (2023)
• Gallo, C. et al. Sulfavant A as the first synthetic TREM2 ligand discloses a homeostatic response of dendritic cells after receptor engagement. Cellular and Molecular Life Sciences 79, 369 (2022).
• Gallo C, et al. A New Bioassay Platform Design for the Discovery of Small Molecules with Anticancer Immunotherapeutic Activity. MARINE DRUGS, vol. 18 (2020)
• Manzo, E. et al. A new marine-derived sulfoglycolipid triggers dendritic cell activation and immune adjuvant response. Scientific Reports, vol. 7 (2017)

mass spectrometry (MS), nuclear magnetic resonance (NMR), mass cytometry (Cytof), mass imaging, flow cytometry