Antonella Prisco

antonella.prisco@igb.cnr.it
+39-081-6132316
https://www.igb.cnr.it/index.php/antonella-prisco/

Institute
Institute of Genetics and Biophysics “Adriano Buzzati Traverso, CNR
Via Pietro Castellino 111, 80131 Napoli
Tel. +39 0816132698
http://www.igb.cnr.it

Luca Pugliese

My research focuses on identifying correlates of the magnitude and duration of immunological memory, with particular attention to inter-individual differences. We combine mouse experiments, human clinical data analysis, and computational modeling. My group developed prototype vaccines displaying a B cell epitope on multimeric proteins or phage capsids, and studied how dosing protocols affect memory formation. We currently model responses to COVID-19 infection and vaccination. In collaboration with physicist Mario Nicodemi, I also developed statistical mechanics models of genome architecture and gene regulation, validated by simulations and experimental data.

• In-silico evaluation of adenoviral COVID-19 vaccination protocols: Assessment of immunological memory up to 6 months after the third dose P Stolfi, F Castiglione, E Mastrostefano, I Di Biase, S Di Biase, G Palmieri, A Prisco Frontiers in immunology 13, 998262
• Vaccination against β-Amyloid as a Strategy for the Prevention of Alzheimer’s Disease FMantile, A Prisco Biology 9 (12), 425
• Comparison of the Hi-C, GAM and SPRITE methods using polymer models of chromatin L Fiorillo, F Musella, M Conte, R Kempfer, AM Chiariello, S Bianco, A Kukalev, I Irastorza-Azcarate, A Esposito, A Abraham, A Prisco, A Pombo, M Nicodemi Nature methods 18 (5), 482-490
• How the interval between prime and boost injection affects the immune response in a computational model of the immune system F Castiglione, F Mantile, P De Berardinis, A Prisco
• Computational and mathematical methods in medicine 2012 (1), 842329 Thermodynamic pathways to genome spatial organization in the cellnucleus M Nicodemi, A Prisco Biophysical journal 96 (6), 2168-2177

Mathematical modeling, simulations