Fabrizio Antonangeli

fabrizio.antonangeli@cnr.it | +39 0649255126
https://www.ibpm.cnr.it/go/fabrizio-antonangeli

Institute
Institute of Molecular Biology and Pathology (IBPM)
c/o Department of Molecular Medicine, Sapienza University of Rome
viale Regina Elena 291, 00161 Rome
https://www.ibpm.cnr.it

Gabriele Favaretto

Cancer immunology and immunotherapy, with particular emphasis on innate immunity (natural killer cells, neutrophils, macrophages, and microglia) and immune surveillance of tumor cells upon chemotherapy. Induction of cellular senescence as stress response to antitumor drugs and its immunomodulatory effects.  Characterization of the senescence-associated secretory phenotype (SASP), an inflammatory secretome of senescent cells that drives chronic inflammation during cancer progression and ageing. Microbiota impact on the functions of the immune system against brain tumors.

• “Neutrophil-activating secretome characterizes palbociclib-induced senescence of breast cancer cells”. Favaretto G, Rossi MN, Cuollo L, Laffranchi M, Cervelli M, Soriani A, Sozzani S, Santoni A, Antonangeli F. Cancer Immunol Immunother. 2024 May 2;73(6):113. doi: 10.1007/s00262-024-03695-5.
• “The senescence journey in cancer immunoediting”. Zingoni A, Antonangeli F, Sozzani S, Santoni A, Cippitelli M, Soriani A. Mol Cancer. 2024 Apr 1;23(1):68. Review doi: 10.1186/s12943-024-01973-5.
• “Regulation of PD-L1 expression by NF-kB in cancer”. Antonangeli F, Natalini A, Garassino MC, Sica A, Santoni A, Di Rosa F. Front Immunol. 2020 Nov 25;11:584626. Review. doi: 10.3389/fimmu.2020.584626.
• “Gut microbiota alterations affect glioma growth and innate immune cells involved in tumor immunosurveillance in mice”. D’Alessandro G*, Antonangeli F*, Marocco F, Porzia A, Lauro C, Santoni A, Limatola C. Eur J Immunology, 2020 May;50(5):705-711. *contributed equally. doi: 10.1002/eji.201948354.
• “Natural killer cell recognition of in vivo drug-induced senescent multiple myeloma cells”. Antonangeli F, Soriani A, Ricci B, Ponzetta A, Benigni G, Morrone S, Bernardini G, Santoni A. Oncoimmunology. 2016 Aug 5;5(10):e1218105. doi: 10.1080/2162402X.2016.1218105

cell cultures, flow cytometry, microscopy