Christine Nardini

christine.nardini@cnr.it
URL (group home page) : https://www.iac.cnr.it/personale/christine-nardini

Institute
Institute for applied mathematics “Mauro Picone” – (IAC)
Via dei Taurini 19 – Rome
https://www.iac.cnr.it

Luigi Manni, Alessandro Ravoni, Veronica Paparozzi

We are interested in the anti-inflammatory effects of physical stimuli, which include the study of mechano-, magneto-, opto- and electro- transduction and their interaction with the immune system and mostly with the innate immune response/inflammation. We work with computational (SBML pathways reconstruction, network biology analyses, machine learning) and experimental approaches (3D bioconstructs, animal models, pilot clinical trials) where we mostly analyze omics include transcriptomics and methylomics including methylage. For this reason the group is highly interdisciplinary involving (neuro)physiologists, computer scientists, engineers, mathematicians but also sociologists and medical anthropologists.

• Veronica Paparozzi, Reyhaneh Hooshmandabbasi, Alessandro Ravoni, Ying Ma, Luigi Manni,Timothy J Koh, Caroline Maake, Tiziana Guarnieri, Darong Lai, Vitalii Zablotskii, Christine Nardini* (2025) Anti‐inflammatory effects of physical stimuli: the central role of networks in shaping the future of pharmacological research, British Journal of Pharmacology, doi 10.1111/bph.70129 in press
• Di Pietro, Biagio; Villata, Simona; Plaksienko, Anna; Guarnieri, Tiziana; Dal Monego, Simeone; Degasperi, Margherita; Di Lena, Pietro; Licastro, Danilo; Angelini, Claudia; Frascella, Francesca; Napione, Lucia; Nardini, Christine*. (2025). Modified Methylation Following Electrostimulation in a Standardized Setting – Complementing a Transcriptomic Analysis. CELLS, 14(11), 838-851 [10.3390/cells14110838].
• BiagioDi Pietro, SimonaVillata, SimeoneDal Monego, MargheritaDegasperi, VeronicaGhini, TizianaGuarnieri, AnnaPlaksienko, YuanhuaLiu, ValentinaPecchioli, LuigiManni, LeonardoTenori, DaniloLicastro, ClaudiaAngelini, FrancescaFrascella, LuciaNapione*, ChristineNardini*, Differential Anti-Inflammatory Effects of Electrostimulation in a Standardized Setting, J. Mol. Sci. 2024, 25(18), 9808; https://doi.org/10.3390/ijms25189808
• Di Lena P, Sala C, Nardini C, Evaluation of different computational methods for DNA methylation-based biological age, Briefings in Bioinformatics, 2022, bbac274, https://doi.org/10.1093/bib/bbac274
• MG Maturo, M Soligo, L Manni, G. Gibson, C. Nardini*, The greater Inflammatory Pathway – High clinical potential by innovative predictive, preventive and personalized medical Approach, EPMA Journal, volume 11, pages1–16(2020), doi: 10.1007/s13167-019-00195-w

multiomics, 3-D bioprint

This is an inter-institute research group involving scientists in and out CNR. Publications are chosen among the newest ones.