Giulia Cappelli

+39 06 49934219 | giulia.cappelli@cnr.it

Institute
Institute for Biological Systems
Provincial Road 35d, 9 00010 Montelibretti (RM)
https://www.isb.cnr.it/

Giulia Cappelli , Denise Campagna, Francesca Mariani.

Experience in molecular biology, immunology and infectious disease. Research on human innate immune response vs intracellular infections (Mycobacterium tuberculosis and S.aureus and HIV) and tumors, to identify the regulation of a protective inflammatory response. Screening of new compounds with potential an antibacterial and anti-inflammatory activity to overcome the resistance insurgence problem of conventional antibiotics. Identification and characterization of African plants products as new nutraceutics or/ and antimicrobial compounds. Development of a technological platform for the in vitro evaluation of the antiviral potency of natural products using pseudoviruses.

• Integrated Seroprevalence and Genome-Based Study of SARS-CoV-2 Viral Strains in N’Djamena: Insights Into Chad’s COVID-19 Epicenter. J Med Virol. 2025 Feb;97(2):e70234. doi: 10.1002/jmv.70234. PMID: 39967351; PMCID: PMC11836593
• Predictive Efficacy of Dual Therapies Combining Integrase Strand Transfer Inhibitors with Second-Generation Non-Nucleoside Reverse Transcriptase Inhibitors Following HIV-1 Treatment Failure in Cameroon: Implications for the Use of a Long-Acting Therapeutic Strategy in Low- and Middle-Income Countries. 2024 Nov 29;16(12):1853. doi: 10.3390/v16121853. PMID: 39772163; PMCID: PMC11680099
• Performance characteristics of INDICAID antigen rapid diagnostic test on SARS-CoV-2 samples during the omicron wave in Cameroon. Heliyon. 2024 Apr 19;10(9):e29937. doi: 10.1016/j.heliyon.2024.e29937. PMID: 38694118; PMCID: PMC11058880
• Computational and experimental validation of phthalocyanine and hypericin as effective SARS-CoV-2 fusion inhibitors” J Biomol Struct Dyn. Pagina 5 – Curriculum vitae Giulia Cappelli 2023 May 26:1-15. doi: 10.1080/07391102.2023.2216276.
• Cappelli G et al. Cinnamomum zeylanicum Blume Essential Oil Inhibits Metastatic Melanoma Cell Proliferation by Triggering anIncomplete Tumour Cell Stress Response International Journal of Molecular Sciences, 2023, 24(6),

Human cell isolation and culture, in vitro infection ( bacteria such as Mycobacterium tuberculosis and S.aureus, Salmonella spp, ESKAPE bacteria  virus and psedudovirus), gene expression (real-time PCR). Antibodies and protein detection (ELISA, Elispot, immunofluorescence ) Institute platform: liquid, solid solid-state spectrometer , NMR, luminometer HPLC )

Deep experience in technological transfer activities ( as expert of Italian cooperation, UNESCO and Head of Italian cooperation (MAE/ISS) support program and Head of Technical Section at CIRCB,Cameroon.) and project management developed in different African countries. Actually PI for the ISB in 3 African cooperation projects.
Organisational competences in the coordination of national program for HIV neonatal diagnosis, HIV resistance test and research activities in HIV/AIDS sector.