Structural Biology
Group Leader : Sonia Covaceuszach
Institute of Crystallography
Key words: Cancer, Tumour-associated biomarkers, Autoantigens, Multifunctional proteins
Contact
Sonia Covaceuszach
39-040-3757526 | 39-040-3757525 | 39-040-3757520 | 39-040-3757527
sonia.covaceuszach@ts.ic.cnr.it
Institute of Crystallography
Area Science Park – S.S. 14 Km 163.5 BASOVIZZA 34149 TRIESTE (IT)
Tel. +39 0503757523
http://www.ic.cnr.it
Lab Members
- Alberto Cassetta (Ricercatore) alberto.cassetta@ts.ic.cnr.it);
- Alessandro Pesaresi (Ricercatore) alessandro.pesaresi@ts.ic.cnr.it
- Doriano Lamba (Primo Ricercatore) doriano.lamba@ts.ic.cnr.it
Activities
- Structural and functional studies of neurotrophins and pro-neurotrophins
- Neurotrophins and pro-neurotrophins interactions with endogenous ligands (ATP, lipids, metals, etc.) and with neutralizing antibodies
- Structure-based humanization of antibodies
Istrument & technologies
- Cloning and heterologous proteins expression (E.coli); Protein refolding; Protein purification
- Proteins biophysical characterization (Circular Dichroism; Dynamic Light Scattering, Differential Scanning Fluorimetry, Isothermal Titration Calorimetry; Surface Plasmon Resonance
- High throughput crystallization screening
- Macromolecular X-ray crystallography at synchrotron radiation sources
- Small angle X-ray scattering in solution at synchrotron radiation sources
- Biomolecular simulations (molecular dynamics, docking, virtual screening)